低剂量三氯化钐对糖尿病大鼠胰岛细胞分泌功能的调节作用

Regulation of the low dose of samarium chloride on the secretory activity of pancreatic islet cells from diabetes rat

本研究工作以健康成年雄性Ｗｉｓｔａｒ大鼠为对象，分４组：（１）对照组；（２）糖尿病组；（３）预防加治疗组；（４）治疗组。第２、３、４组均应用ＳＴＺ制成糖尿病大鼠，其中３、４组应用低剂量三氯化钐（０．０５ｍｇ／ｋｇ）治疗６周后，采用放射免疫检测术测定了各组动物血浆中胰岛素、胰高血糖素、生长抑素及血糖的变化。实验结果表明：经使用低剂量三氯化钐治疗后的第（３）、（４）组动物均活泼、状态良好，体重增加，血浆中胰岛素水平增高及生长抑素水平下降，均与正常对照组近似；胰高血糖素及血糖水平均呈下降趋势。由此可见，低剂量三氯化钐对糖尿病大鼠胰岛细胞分泌功能具有调节作用，从而使糖尿病大鼠的健康状况得以明显改善。

In order to study the effect of the low dose of samarium chloride (SmCl3,005 mg/kg) on the cells secretory activity of pancreatic islet from diabetes rat,the radioimmunoassay was used.The rats were divided into four groups,they respectively were control,diabetes control,treatment with preventive and treatment group.The model of diabetes rat was made by routine STZ (Streptozotocin) method.For the rats in treatment with preventive group, they were administrated the low dose of SmCl3 every other day for two weeks by intraperitoneal,then the model of diabetes rat was made, and finally diabetes was treated using the low dose of SmCl3 for six weeks.The results showed that the rats in control groups were strong and active,their body hair was smooth and shine,their body weight increased notably.However,the rats in diabetes control group were thin,weak and inactive,their body weight decreased,the level of plasma insulin lowered obviously,the level of glucagon,somatostatin and blood sugar increased as compared with the control group.The rats in treatment with preventive group and treatment group appeared to be in good health,there was no difference in the level of insulin and somatostatin as compared with control group,and the level of glucagon and blood sugar lowered as compred with diabetes control group.From these evidences mentioned above the secretory activity of pancereatic islet cells can be regulated by the low dose of SmCl3,so the health of diabetes rats was made better.