依达拉奉治疗急性脑出血临床疗效观察

Clinical observation on effects of edaravone in the treatment of acute cerebral hemorrhage

目的观察依达拉奉(MCI-186)治疗急性脑出血的临床疗效。方法选择符合条件的持续入院的脑出血患者60例,随机分为治疗组和对照组各30例。对照组根据出血量给予常规治疗。治疗组在对照组治疗基础上,给予依达拉奉30mg,bid,共14d。治疗后第28天对两组患者进行神经功能缺损评分及疗效评定。结果治疗28d后,治疗组神经功能缺损评分由治疗前的(18.6±6.7)分下降到治疗后的(9.4±5.3)分(P<0.05);对照组神经功能缺损评分由治疗前的(19.4±10.4)分下降到治疗后的(15.6±9.7)分,但差异无统计学意义(P>0.05);两组治疗后比较差异有统计学意义(P<0.05)。治疗组无明显不良反应。结论依达拉奉能有效改善急性脑出血患者的神经功能缺失。

Objective To observe the clinical therapeutic effects of edaravone on acute cerebral hemorrhage. Methods 60 patients with acute cerebral hemorrhage according with the diagnostic criteria were randomly divided into two groups （the trial group and control group）. Routine treatments were used in patients of the control group according to the extent of the cerebral hemorrhage. On the basis of routine treatments, patients of the trial group were given each 30 mg of edaravone dissolved in 250ml of 0.9% sodium chloride solution administered by intravenous instillation, bid, for 14 consecutive days. The neurological functional deficit scores and assessment of the therapeutic effectiveness in patients of both groups were carried out at 28 days after the termination of the treatment course. Results In patients of the trial group, the neurological functional deficit scores was 18.6：L-6.7 before the treatment signitlcantly dropped to a low value of 9.4±5.3 （P〈0.05） 28 days after the termination of the treatment. In patients of the control group, the pre-treatment the neurological functional deficit scores was 19.4±10.4 dropped to a post-treatment value of 15.6±9.7 （P〉0.05） 28 days after the termination of the treatment; but no significant difference. The post-treatment neurological functional deficit scores in patients of the trial group were significantly lower than that in patients of the control group （P〈0.05）. No major adverse reactions were encountered in patients of the trial group. Conclusion Edaravone may efectively improve the nervous function in patients with acute cerebral hemorrhage.