两种海藻多糖对大鼠脂质代谢和血小板功能的比较

Comparison of Effects of Two Kinds of Soluble Algae Polysaccharide on Blood Lipid, Liver Lipid, Platelet Aggregation and Growth in Rats

为了研究可溶性海藻多糖的营养作用，以含１％胆固醇和０．２％胆盐的高胆固醇饲料分别加入海藻酸钠和卡拉胶两种可溶性海藻多糖，作为海藻酸钠与卡拉胶两个试验组动物饲料；不加海藻多糖的饲料用于对照组，喂养ＳＤ大鼠８周。实验表明，５％的海藻酸钠可使血脂、肝脂质和血小板聚集性下降，且不影响大鼠摄食和生长。添加５％或１０％的卡拉胶对降血脂和肝脂没有显著效果，不能降低肝／体重量比，对血小板聚集性的降低作用也不稳定（或不肯定）。１０％的卡拉胶使大鼠的平均体重增重减少了１２．１７％（Ｐ＞０．０５）。

SD rats were fed with 1% cholesterol and 0.2% cholate for eight weeks. Sodium alginate and carrageenan, two kinds of soluble algae polysaccharide, were added to the fodder for the trial groups and none added for the control one. Results showed that 5% sodium alginate could lower lipid levels in the blood and liver and platelet aggregation (P<0.05) in rats, but not affect their food intake and growth. Addition with 5% or 10% carrageenan had no obvious effects on lowering blood lipid and liver total cholesterol (P>0.05), could not lower the ratio of liver weight to body weight, and had no stable (or sure) effect on lowering platelet aggregation. Ten percent of carrageenan could decrease their mean body weight by 12.17% in rats (P>0.05), but a few rats suffered from slight diarrhea.