福建省肝炎病毒感染家庭聚集性研究

A Study on Familial Aggregation of Hepatitis Virus Infection in Fujian Province

为了研究福建省肝炎病毒感染的家庭聚集性，应用二项分布分析法，对福建省９个疾病监测点正常人群中１２３７户家庭的抗－ＨＡＶ、ＨＢｓＡｇ、抗－ＨＣＶ、抗－ＨＥＶ阳性分布进行分析。结果显示，除了抗－ＨＣＶ外，抗－ＨＡＶ、ＨＢｓＡｇ、抗－ＨＥＶ二项式分布χ２值分别为４９．８９、２１７．９１、２７．３９，Ｐ值均小于０．００１，表明均有极明显的家庭聚集性，聚集率分别为８４．１３％、３４．８３％和３５．２３％。研究结果提示，家庭聚集性主要是母婴传播和家庭内水平传播。

In nine disease surveillance points of Fujian Province, positive serum antibody against hepatitis A virus (antiHAV), hepatitis B surface antigen (HBsAg), antibody against hepatitis Cvirus (antiHCV) and antibody against hepatitis E virus (antiHEV) in people of 1 237 families were determined and their distribution was analyzed to study familial aggregation of hepatitis virus infection by fitting to binomial distribution. Results showed that χ2 of goodnessoffit to binomial distribution was 49.89, 217.91 and 27.39 for antiHAV, HBsAg and antiHEV respectively, all with P<0.001, indicating very obvious familial aggregation in HAV, HBV and HEV infection, with aggregation rates of 84.13%, 34.83% and 35.23% respectively. It suggests that familial aggregation is mainly caused by mother to infant transmission and horizontal transmission in families, and HEV infection can be transmitted through sex.