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锰超氧化物歧化酶抑癌作用的研究进展 被引量：2

Advance in role of tumor suppressed by manganese superoxide dismutase
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摘要 锰超氧化物歧化酶（manganese superoxide dismutase，MnSOD）是真核细胞内重要的抗氧化酶。它是潜在的新型肿瘤抑制基因，具有抑制肿瘤细胞生长的功能，在肿瘤中表达异常。此文综述了MnSOD抑癌作用及其作为肿瘤基因治疗新靶位的研究进展。 Manganese superoxide dismutase （MnSOD） is the major antioxidant enzyme in eukaryocytes. It is a new potent type of tumor-suppressor gene. It can inhibit the growth of tumor, but its expression is abnormal in tumor. This review briefly highlights recent advance about the role of tumor suppressed and update of gene therapy targeted on MnSOD.
作者 操敏 李琦
机构地区 北京市结核病胸部肿瘤研究所呼吸科
出处 《国际呼吸杂志》 2008年第18期1128-1131,共4页 International Journal of Respiration
关键词 锰超氧化物歧化酶 抑癌基因 临床研究 治疗方法 Manganese superoxide dismutase Tumor-suppressor gene
分类号 R730 [医药卫生—肿瘤]
  • 相关文献

参考文献19

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共引文献3

同被引文献28

  • 1刘秀芳,夏云飞,李满枝,贺玉香,郑美莲,蒋昌斌.不同p53功能状态鼻咽癌细胞株的放射生物学特性[J].中华放射肿瘤学杂志,2005,14(4):335-338. 被引量：8
  • 2Zelko I N, Mariani T J, Folz R J. Superoxide dismutase multigene family: a comparison of the CuZn-SOD(SOD1), Mn- SOD(SOD2), and EC-SOD(SOD3) gene structures, evolution, and expression[J]. Free Radic Biol Med, 2002, 33(3): 337-349.
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  • 5Oberley T D, Zhong W, Szweda L I, et al. Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium[J]. Prostate, 2000, 44(8): 144-145.
  • 6Hur G C, Cho S J, Kim C H, et al. Manganese superoxide dismutase expression correlates with chemosensitivity in human gastric cancer cell lines[J]. Clin Cancer Res, 2003, 15(4): 5768-5775.
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国际呼吸杂志
2008年 第18期

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