中/长链脂肪乳注射液治疗新生儿寒冷损伤综合征疗效观察

Efficiency investigation on the medium and long chain fat emulsion in treating neonatal scleredema

目的：探讨中／长链脂肪乳注射液（C8-24）治疗新生儿寒冷损伤综合征的疗效。方法：将70例新生儿寒冷损伤综合征患儿随机分为治疗组40例，对照纽30例。对照组采用常规综合治疗，治疗组在常规综合治疗基础上加用20％的中／长链脂肪乳注射液静脉滴注，首日剂量0．5g／（kg·d），之后递增至3g/（kg·d），以4～6滴／min，6—10h／d缓慢输入，3—5d为一疗程。结果：总有效率治疗组87．5％，对照组63．3％（Х^2=5．678，P〈0．05）。治疗组硬肿完全消退平均时间（4．4±1．5）d，对照组（6．1±2．8）d，两组比较差异有统计学意义（t=3．18，P〈0．05）。结论：在常规综合治疗基础上加用中／长链脂肪乳注射液静脉滴注对新生儿寒冷损伤综合征治疗有效，能加速硬肿消退、提高治愈率及降低病死率。

Objective ：To investigate the efficiency of the medium and long chain fat emulsion injection in treating neonatal scleredema. Methods： 70 cases with neonatal scleredema were divided into two groups randomly： 30 cases of the control group with routine comprehensive treatment, while 40 cases of the treatment group with medium and long chain fat emulsion injection. Along with routine comprehensive treatment, the treatment group was administrated additional 20% medium and long chain fat emulsion injection, with 0. 5 g/（ kg· d） as initial dose and increased to 3 g/（ kg· d） in the following days, 4 - 6 drops/min, 6 - 10 h/d, 3 - 5 d as one period of treatment. Results： The total effective rate in the treatment group was 87.5%, while 63.3% in the control group （Х^2 = 5. 678, P 〈 0. 05 ）. The average period of scleredema disappearing in the treatment group （4.4 ± 1.5 days） was shorter than that （6.1 ± 2.8 days） in the control group, with a statistic significance （t = 3. 18, P 〈 0.05 ）. Conclusions： Medium and long chain fat emulsion injection is effective in treating neonatal scleredema, which can accelerate fadeaway of hard swollen and decrease the case fatality ratio.