凝血纤溶系统因子与肺癌预后的相关性研究

Prognostic significance of blood coagulation and fibrinolysis disorders in lung cancer

肿瘤患者出现凝血、纤溶系统异常很常见，特别在肺癌患者更为明显。这些异常不仅引起血栓、弥漫性血管内凝血（DIC）等直接危害患者生命，而且在肿瘤的生长、侵袭和转移过程中起重要作用。血小板、促凝物质、D-二聚体、uPA系统因子、抗凝血酶（AT）Ⅲ及凝血酶-抗凝血酶Ⅲ复合物（TAT）等凝血、纤溶系统因子对患者病情及预后具有明显作用。

Coagulation and fibrinolysis disorders are very common in cancer patients, especially in lung cancer patients. These disorders not only cause thrombosis and diffuse intravascular coagulation, but also play a critical role in cancer growth, invasion and metastasis. Coagulation and fibrindysis system factors, such as platelet, procoagulant, D-dimer, uPA factors, AT Ⅲ and TAT, have obvious prognostic significance in lung cancer.