5-脂氧酶与小鼠肺部感染的关系

RELATIONSHIP BETWEEN 5-LIPOXYGENASE AND LUNG INFECTION OF MICE

目的探讨小鼠肺组织内5-脂氧酶(5-LO)与呼吸道感染的关系。方法采用免疫组织化学方法检测24只小鼠肺组织内5-LO的表达。结果感染组小鼠5-LO阳性强度比未感染组高;治疗组小鼠5-LO的表达强度降低。结论小鼠肺组织5-LO的表达强度,对临床及科研中肺感染疗效的评价有一定参考价值。

Objective To investigate the relationship between the 5-1ipoxygenase（5-LO） in mouse lung and during infection in the respiratory system. Methods Investigate the expression of 5-LO in the lung of a mouse by immunocytochemistry. Results The intensity of the immune staining against 5-LO antibody was stronger in infected mice than that in non-infected rats. A weaker was observed in the treated group of animals. Conclusion Changes in the expression of 5-LO in pulmonary tisssues could be designed to detect the treatment efficacy during the lung infection.