IL-10基因启动子-1082、-592、-819位点多态性与HBV易感性关系的荟萃分析

A meta-analysis of the relation of polymorphism at the sites-1082,-592 and -819 of IL-10 gene promoter with the susceptibility to hepatitis B virus infection

目的调查白细胞介素10(IL-10)基因启动子区-1082、-592、-819位点多态性与乙型肝炎病毒(HBV)易感性的关系。方法在CNKI,Medline,ISI等数据库中使用interleukin-10,polymorphism,hepatitis B virus以及相应的中文名等关键词进行检索,筛选1985年1月-2007年12月间发表的关于IL-10基因启动子多态性与HBV易感性关系的研究文献,最终纳入9篇文献,累计病例3 034例,对照1 289例。结果-1082位点AA、AG基因型的存在与感染HBV无关联(P>0.05),而存在GG基因型时不易感染HBV(P<0.01);等位基因A、G的频率均与HBV感染无关联(P>0.05)。-592位点AA、AC、CC基因型的存在及等位基因A、C的频率均与HBV感染无关联(P>0.05)。-819位点TT基因型的存在与HBV感染无关联(P>0.05),而TC基因型的存在可增加HBV感染的危险(P<0.01),CC基因型的存在可降低HBV感染的危险(P<0.01);等位基因T、C的频率与HBV感染无关联(P>0.05)。结论IL-10启动子区-1082位点GG基因型、-819位点CC基因型的存在降低了HBV感染的风险,-819位点TC基因型的存在增加HBV感染的风险。其余各位点基因型的存在及各等位基因的频率与HBV感染风险均无关联。

Objectives To investigate the relation between the polyphmorphism of the sites -1082, -592 and -819 in the promot er region of interleukin （IL）-10 gene and susceptibility to hepatitis B virus （HBV） infection. Methods Using key words, including inter leukin 10, polymorphism, hepatitis B virus and corresponding Chinese words were used to retrieve from the literature, the articles concerning the relationship between interleukin （IL）-10 gene promoter polymorphisms and the susceptibility to HBV infection, published from Jan. 1985 to Dec. 2007, and those presented in the database CNKI, Medline and ISI. A total of 3 034 cases and 1 289 controls were ob tained. Results The presence of AA and AG genotypes at the site -1082 of II-10 gene promoter region showed no association with the risk of HBV infection （P〉0. 05）, while the presence of GG genotype was significantly associated with a decreased risk for HBV infection （P〈0. 01）. Furthermore, the frequencies of allele A and allele G showed no association with HBV infection （P〉0. 05）. For the site -592, the presence of AA, AC and CC genotypes and the frequencies of alleles A and C showed no relation with the risk of HBV infection （ P〉0. 05）. Regarding the site 819, the presence of TT genotype showed no association with the risk of HBV infection （P〉0.05）. However, the presence of TC genotype was significantly associated with an increased risk of HBV infection （ P〈0. 01）. In contrast, the presence of CC genotype was significantly associated with a decreased risk of HBV infection （P〈0. 01）. In addition, alleles T and C were not associated with the risk of HBV infection （P〉0. 05）. Conclusions The presence of GG genotype at the site --1082 and CC genotype at the site 819 are significantly associated with decreased risk of HBV infection, while the presence of TC genotype at the site -819 is associated with an increased risk of HBV infection. The presence of other genotypes and the frequencies of all the alleles are not associated with the risk of HBV infection.