含维生素C纳米粒子的制备及性能研究

Study of preparation and properties of nanoparticles containing Vitamin C

以生物相容性好的α-氰基丙烯酸正乙酯为原料,采用界面聚合的方法制备含维生素C(Vc)的纳米粒子,探讨了制备纳米粒子的较佳条件,并通过傅立叶红外光谱仪(FTIR)、动态激光光散射仪(DLS)、高分辨率透射电镜(TEM)和荧光光谱分别对制得的含Vc的纳米粒子性能进行了研究。结果表明,所得含Vc的纳米粒子平均粒径为280 nm;粒子形貌为具有壳-核结构的球形粒子;粒子中Vc的载药率为17.6%。在不同温度下对比加速老化实验证明,纳米粒子中的Vc的稳定性远高于水溶液中的Vc,且在温度越高的情况下,这种现象越明显,证明纳米粒子对Vc有良好的保护作用。

Biocompatible poly（ ethyl α -cyanoacrylate） was used to prepare nanoparticles containing Vitamin C （Vc） by interracial polymerization. The optimal conditions of polymerization were investigated. The properties of nanoparticles containing Vc were studied by Fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscopy and fluorescence spectroscopy respectively. The results showed that the average size of nanoparticles is 280 nm and its distribution is homogeneous. The morphology of nanoparticles is spherical with the shell - core structure and drug loading ratio of Vc is 17.6%. Comparison of results got from accelerated aging test under different temperature showed that the stability of Vc in nanoparticles is much higher than that in aqueous solution. Obviously, the nanoparticle preparation can protect the stability of Vc effectively.