鱼腥草药材挥发油及其注射剂中癸酰乙醛的研究考证

Identification and verification of decanoyl acetaldehyde and its existence in essential oil from Hottuynia cordata Thunb.and its injection

目的:对鱼腥草药材挥发油及其注射剂中抗菌成分癸酰乙醛是否存在进行研究考证。方法:采用 LC-MS/MS 的一级质谱全扫描、选择性离子检测和子离子扫描方式对癸酰乙醛进行分析确证,以 GC-MS 和 GC-FID 进行佐证。结果:多种分析手段一致确证了鱼腥草药材挥发油中含有癸酰乙醛,而注射剂中却未检出。结论:鱼腥草注射液现有生产工艺和产品标准仅对化学成分甲基正壬酮进行分析控制,没有对挥发油中具有药理活性的癸酰乙醛进行测定控制,有待改进。

Objective：To identify and verify the existence of decanoyl acetaldehyde, the main antibacterial component, in the essential oil from Hottuynia cordata Thunb. and its injection. Method ： LC - MS/MS fullscan, SIM and product - scan analyses were carried out for the determination. GC - MS and GC - FID were also used for the verification. Results：All the means of determination came to the same results that decanoyl acetaldehyde was present in the essential oils of the fresh and dried herbs, while it was not found in the injection. Conclusion ： The present injection and the compendium standard of the essential oil from Hottuynia cordata Thunb. using the content of 2 - undecanone as the quality indicator, without controlling the content of decanoyl acetaldehyde, the active ingredient in the essential oil, should be re -evaluated.