国产奥卡西平治疗儿童良性癫痫伴中央颞区棘波的疗效观察

Efficacy of domestic oxcarbazepine on children with benign epilepsy with centrotemporal spikes

目的:观察国产奥卡西平(OXC)治疗儿童良性癫痫伴中央颞区棘波(BECT)的疗效、安全性和耐受性。方法:用国产OXC单药治疗30例BECT患儿,分析治疗后1,2,3,6个月的疗效和不良反应。OXC起始剂量为5～10mg.kg-1.d-1,每隔1周增加1次剂量5～10mg.kg-1.d-1,维持剂量20～30mg.kg-1.d-1。结果:本组总有效率为86.67,服药6个月时累积控制率为73.33,留存率为93.33。结论:国产OXC治疗BECT的疗效明显,不良反应轻,耐受性好,安全性高。

OBJECTIVE To evaluate the efficacy, safety and tolerability of domestic oxcarbazepine as monotherapy in patients with benign epilepsy with centrotemporal spikes. METHODS A retrospective chart review identified 30 patients with BECT receiving oxcarbazepine monotherapy, analysing the efficacy and adverse events of 1,2,3,6months treatment. During a 6-month treatment phase, monotherapy was initiated 5 - 10mg·kg^-1·d^-1. Dose escalation was 10 mg·kg^-1·d^-1 in weekly increments titrated up to 20 - 30 mg·kg^-1·d^-1. RESULTS Overall, 86. 67% of patients experienced a ≥50% reduction in seizure frequency, and 73.33% were seizure-free in 6 months. Subsist rate was 93. 33%. CONCLUSION These findings suggest that oxcarbazepine monotherapy is effective, safe and well tolerated in patients with benign epilepsy with centrotemporal spikes.