抗抑郁药治疗缺血性脑血管病合并功能性消化不良患者情绪障碍的疗效观察

Clinical Efficacy of Antidepressants for Emotional Disorder in Patients with Ischemic Cerebral Vascular Diseases Combined Functional Dyspepsia

目的:探讨抗抑郁药对缺血性脑血管病合并功能性消化不良(FD)患者情绪障碍的疗效。方法:治疗前对36例健康人(对照组)和36例缺血性脑血管病合并功能性消化不良患者(治疗组)进行SCL-90评分;治疗组应用抗抑郁药盐酸氟西汀治疗,疗程为8周,治疗后再进行SCL-90评分。结果:治疗组和对照组在躯体和精神症状方面存在显著性差异(P<0.01);治疗组在接受抗抑郁药治疗8周后,前后评分对比,患者精神和躯体症状均有明显改善(P<0.01)。临床症状亦改善明显。结论:缺血性脑血管病合并功能性消化不良患者普遍存在抑郁和焦虑情绪,应用抗抑郁药治疗能明显改善患者的症状。

OBJECTIVE： To observe the curative efficacy of antidepressants for emotional disorder in patients with ischemic cerebral vascular diseases combined functional dyspepsia. METHODS： 36 healthy volunteers （control group） and 36 patients with ischemic cerebral vascular diseases combined functional dyspepsia （trial group） were scored with SCL- 90 before and after treatment. The trial group was treated with Fluoxetine hydrochloride for 8 weeks. RESULTS： There were significant differences between the two groups in physical and psychological syndrome （P 〈 0.01）. As compared with before treatment, there were significant improvement in physical and psychological syndrome scores in patients after 8 - week treatment with antidepressants （P 〈 0.01）, and their clinical symptoms were also improved significantly. CONCLUSION： Depression and anxiety were common in patients with ischemic cerebral vascular diseases combined functional dyspsia, however, which can be improved by antidepressants.