硫氧化还原蛋白还原酶在58例肺腺癌中的表达

Thioredoxin reductase1 mRNA expression in 58 cases with lung adenocarcinoma

目的:探讨硫氧化还原蛋白还原酶(thioredoxin reductase,TrxR1)mRNA在58例肺腺癌中的表达及其临床意义。方法:原位杂交法检测58例肺腺癌蜡块组织和10例癌旁正常肺组织中TrxR1 mRNA的表达。结果:TrxR1 mRNA在肺腺癌组织中的表达高于癌旁正常组织,但差别无统计学意义(P>0.05),在低分化组织中表达阳性率高于中高分化组织,差别具有统计学意义(P<0.05)。在直径小于3cm,3cm-5cm之间及大于5cm的肺腺癌组织中的表达差别具有统计学意义(P<0.05),在有淋巴结转移的肺腺癌组织中表达高于无淋巴结转移者,差别具有统计学意义(P<0.05)。结论:TrxR1 mRNA的表达与肺腺癌之间有密切的关系。

Objective：To investigate the expression of thioredoxin reduetasl （TrxR1）mRNA in 58 cases with lung adenocarcinoma. Methods： The expression of TrxRlmRNA was detected in 58 cases lung adenocarcinoma tissues and 10 cases adjacent normal lung tissues by means of hybridization in situ. Results： The positive rate of TrxR1 mRNA in lung adenocarcinoma tissues was 32. 8% ,higher than that in adjacent normal lung tissues which was 20% （ P 〉 0.05 ）. TrxR1mRNA was related to the degree of differentiation, the positive rate in low degree of differentiation was higher than that in high degree （P 〈 0.05 ）, expression of TrxR1 mRNA was significantly different between less than 3cm,3 -5cm and over 5cm on diameter（P 〈 0.05）. The difference of the expression of TrxR1mRNA in the patients with and without lymph nodes metastasis was also significant （P 〈 0.05）. Conclusion： The expression of TrxR1 mRNA was closely related to lung adenocarcinoma.