c-met蛋白在大肠癌组织的表达及其与肿瘤肝转移的关系

Expression of c-met protein in colorectal cancer and the correlation with liver metastasis

目的:探讨c-met蛋白在癌旁正常大肠黏膜,大肠腺瘤,大肠癌组织中的表达及其与大肠癌发生、发展、肝转移的关系。方法:免疫组化法检测癌旁正常大肠黏膜,大肠腺瘤,大肠癌组织与肝转移灶组织中c-met蛋白表达水平,分析其与大肠癌病理分化程度,淋巴结转移及肝转移的关系,并比较同期切除的肝转移灶与原发灶表达水平的差异。结果:c-met蛋白在正常大肠黏膜,大肠腺瘤中表达明显低于大肠癌;有淋巴结转移的大肠癌组织中,c-met蛋白表达明显高于无淋巴结转移者;有肝转移的大肠癌组织中c-met蛋白明显高于无肝转移者。结论:c-met在大肠癌发生、发展、转移中起重要作用;c-met蛋白对大肠癌肝转移有一定的预测作用。

Objective：To investigate the expression of c - met protein in surrounding normal colorectal tissue, colorectal adenoma, colorectal cancer, and the correlation with development and livermetastasis of colorectal cancer. Methods ： The expression of c - met protein was detected by SABC immunohistochemical method in normal coloreetal mucosa, colorectal adenoma, colorectal tissue with no preoperation liver metastasis , 13 liver metastasis tissue and corresponding primary cancer tissue of synchronic hepatic metastasis were analyzed to demonstrate the correlation with the histological grade, Dukeg stages ,lymph nodemetastasis and liver metastasis. Results： The expression level of c -met protein in normal colorectal mucosa and colorectal adenoma were significantly lower than that in colorectal cancer. The expression of c - met protein in colorectal cancer with lymph node metastasis was significantly higher than that with no lymph node metastasis. The expression of c - met in colorectal cancer with liver metastasis including synchronic hepatic metastasis and heterochronic hepatic metastasis were significantly higher than that with no liver metastasis. Conclusion： c -met protein plays a great role in the course of generation, development and metastasis of coloreetal cancer. The high expression of c - met protein in colorectal cancer tissue may be considered as an indicator for hepatic metastasis of colorectal cancer.