血清CA125水平与淋巴瘤细胞浸润及疗效的关系

Correlations between Serum CA125 Level and Infiltration of Lymphoma Cells and Response to Treatment in Patients with NHL

目的探讨血清CA125与非霍奇金淋巴瘤(NHL)细胞浸润及患者疗效的关系。方法采用放射免疫学方法测定103例NHL患者的血清CA125水平,并结合临床特征进行分析。结果约49.5%(51/103)的NHL患者血清CA125增高;血清CA125水平与乳酸脱氢酶(LDH)、骨髓浸润、结外侵犯、浆膜腔积液、巨大肿块、CD20高表达相关(P<0.05),CA125增高者化疗完全缓解率(CR)低,且容易复发(P<0.05)。结论血清CA125水平与淋巴瘤细胞浸润有一定相关性,可作为NHL患者诊断、病情进展及复发预测又一重要的辅助指标。

Objective To investigate the correlations between serum CA125 level and infiltration of lymphoma cells and response to treatment in patients with non Hodgkin＇s lymphoma（NHL）. Methods Ser um CA125 levels in 103 patients with NHL were measured by radioimmunoassay （RIA）, and the associations between CA125 levels and other presenting features were examined. Results CA125 levels were elevated in 49. 5% of patients with NHL. A higher CA125 level was associated with high serum lactate dehydrogenase level, bone marrow involvement, extranodal involvement, and effusions, bulky disease and high expression of CD20（P〈0. 05）. Complete responses were higher in patients with normal CA125 lev els than in patients with elevated CA125 levels, and the latter patients were apt to recurrence. Conclusion There are some correlations between serum CA125 level and infiltration peculiarity of lymphoma ceils. And serum CA125 can be taking as an important auxiliary index to diagnose, advanced disease and evaluation the effectiveness of treatment.