活性糖元保降血糖作用实验研究

Experimental studies on hypoglycemic activity of active hepatin

目的:观察活性糖元保对糖尿病小鼠或大鼠模型的降血糖作用。方法:ICR小鼠皮下注射四氧嘧啶复制糖尿病小鼠模型,灌胃给予活性糖元保1.0、2.0、4.0g/kg剂量(均折算成生药量,下同),每2周检测一次体重以及空腹血糖,连续8周;SD大鼠以小剂量链脲霉素合并高脂饮食诱发2型糖尿病模型,灌胃给予活性糖元保0.75、1.50、3.00g/kg剂量,每2周检测一次体重以及空腹血糖,连续8周;另采用四氧嘧啶诱发的糖尿病小鼠观察其对糖耐量影响。结果:活性糖元保1.0、2.0、4.0g/kg剂量可降低四氧嘧啶所致糖尿病模型小鼠血糖值,并明显改善该模型小鼠糖耐量,减少其血糖曲线下面积;3.00g/kg剂量对小剂量链脲霉素合并高脂饮食诱发的2型糖尿病大鼠血糖也有一定的降低作用。结论:活性糖元保具有一定的调节血糖和改善糖耐量的作用。

AIM： To observe the hypoglycemic activity of active hepatin in diabetic mouse or rat models. METHODS： The diabetic mice induced by alloxan were i.g. given active hepatin 1.0,2.0,4.0 g/kg for 8 weeks. The body weight and fasting blood glucose were determined every 2 weeks. The type ：2 diabetic SD rats induced by fed with high caloric diet and injected minidose streptozocin, were given active hepatin 0.75, 1.50, 3.00 g/kg i.g. for 8 weeks, also the body weight and fasting blood glucose were determined every 2 weeks. In addition, the effect of active hepatin on glucose tolerance was investigated in alloxan-induced diabetic mice. RESULTS： Active hepatin reduced the levels of blood glucose and improved the glucose toler- ance, and also decreased the blood sugar curve areas about alloxan-induced diabetic mice which were given the dosages 1.0,2.0,4.0 g/kg of active hepatin. The blood glucose of type 2 diabetic SD rats induced by fed with high caloric diet and injected with minidose streptozocin could be decreased by 3.00 g/kg of active hepatin. CONCLUSION： Active hepatin can adjust bloodsugar level and improve glucose tolerance.