HIV感染者的血液学检测分析与研究

Detection and analysis of blood indicators in HIV carriers

目的:对HIV感染者做相关的血液学检测,分析HIV感染者合并感染乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)的现状及其预后,为揭示HIV、HBV、HCV混合感染的规律,为预防、治疗及判断HIV混合感染的预后提供科学依据。方法:按照国家检验标准,对我市120例HIV感染者进行CD4+、CD8+T淋巴细胞计数,丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)检测,HBV五项、抗HCV检测,检测结果做相关性和差异性统计学分析。结果:120例HIV感染者中,合并HBV、HCV感染者71例,占所有HIV感染者的59.17%,其中合并HBV感染者50例,占HIV感染者的41.67%,合并HCV感染者39例,占HIV感染者32.5%。HIV/HBV、HIV/HCV、HIV/HBV/HCV3种合并感染者的CD4+T淋巴细胞计数明显低于HIV单一感染者(P均<0.05),HIV/HCV、HIV/HBV/HCV混合感染者的ALT、AST异常比例明显高于HIV单一感染(P均<0.05)。结论:HIV感染者合并HBV、HCV感染现状严重。HIV合并感染肝炎病毒后,可以加速肝脏和免疫系统的损害,导致HIV感染者更高的发病率和死亡率,加快HIV感染者疾病的进程,降低抗逆转录病毒治疗(HAART)的效果,应引起更多的重视,尽早采取措施,提高HIV感染者的防治效果。

Objective：To detect the blood indicators of HIV carriers and to analyze the status and prognosis of single HIV infection and its co-infection with HBV and HCV to provide the scientific references for finding out rules of multiple infection and controlling them.Methods：CD4^＋ and CD8^＋ lymphatic cells in 120 HIV carriers were counted.Their levels of ALT and AST as well as 5 serological indicators related to HBV and anti-HCV were detected according to national standardized detection methods.Correlation and difference were analyzed.Results：Seventy-one of 120 HIV carriers had co-infection with either HBV or HCV or both of them,which accounted for 59.17% of all cases Co-infection with HBV and HCV was 50 and 39,respectively,which took up 41.67% and 32.5% of all cases,respectively.HIV/HBV,HIV/HCV and HIV/HBV/HCV had lower level of CD4^＋ T cells counts than that of single HIV infection（all P〈0.05）.HIV/HCV and HIV/HBV/HCV had higher abnormal percentage of ALT and AST than that of single HIV infection（both P〈0.05）.Conclusion：Co-infection with HBV and/or HCV in HIV carriers has increasingly become frequent.Co-infection with multiple hepatitis viruses can deteriorate liver function and do more damage to immunity system of HIV carriers,which leads to higher mobility and mortality,and affects the prognosis and treatment of HAART.Hence,more attention should be paid for HIV carriers and early and effective measures should be taken.