摘要
目的:评价肿瘤特异生长因子(TSGF)在肺癌诊断中的临床应用价值。方法:测定92例肺癌和63例肺部感染患者、41例肺结核及256例正常人的血清TSGF水平。结果:①肺癌患者血清TSGF水平高于健康对照组(P<0.01)。TSGF诊断肺癌的敏感性为78.3%,特异性为98.0%;②肺部感染患者TSGF水平高于健康人(P<0.01),其假阳性率可达到65.1%,而与肺癌组则无明显差异(P>0.05);③肺结核患者血清TSGF水平与正常对照组无显著差异(P>0.05);④肺部感染患者经抗感染治疗后,血清TSGF下降至正常水平,与正常对照组相比无显著差异(P>0.05)。结论:肺癌患者血清TSGF水平明显增高,在排除炎症后,可作为肺癌辅助诊断的良好指标。
Objective:To evaluate the clinical significance of detection of serum tumor specific growth factor (TSGF) in diagnosing malignant lung cancer. Methods: The TSGF concentration was determined in 92 patients with lung cancer, 63 patients with pulmonary infection, 41 patients with pulmonary tuberculosis and 256 healthy adults. Results : (1)The TSGF level in lung cancer group was higher than that in healthy adult group ( P 〈 0. 01 ), The sensibility rate of diagnosing lung cancer was 78.3%, the specificity to healthy adult was 98% ; (2)The difference of serum TSGF level between pulmonary infection group and healthy adult group was statistically significant (P 〈 0. 01 ), the false positive rate was 65. 1%, and the difference of serum TSGF level between pulmonary infection group and lung cancer group was not statistically significant ( P 〉 0.05 ) ; (3)The difference of serum TSGF level between pulmonary tuberculosis group and healthy adult group was not statistically significant (P 〉 0.05 ). (4)The serum TSGF level in pulmonary infection group with anti - infection treatment was decreased to normal level, and there was no statistical difference compared to the healthy adult group ( P 〉 0. 05 ). Conclusion: The serum TSGF is increased obviously in lung cancer patients, and it may be a good biomarker for diagnosing of the lung cancer after exclusing the pulmonary infection.
出处
《西北国防医学杂志》
CAS
2008年第5期351-353,共3页
Medical Journal of National Defending Forces in Northwest China
关键词
肺癌
肺部感染
TSGF
Lung cancer
Pulmonary infection
Tumor specific growth factor