葛根素干预对糖尿病运动大鼠血清抗氧化能力的影响

Effects of Puererin and Exercise on Antioxidant Capacities of Diabetic Rats Serum

目的:研究运动及补充葛根素对糖尿病大鼠血清抗氧化能力的影响。方法:以注射链尿佐菌素诱导成年雄性SD大鼠成糖尿病模型,观察运动、补充葛根素、运动结合补充葛根素对糖尿病大鼠血清T-AOC、SOD、GSH、GSH-PX、CAT、MDA及胰岛素、血糖的影响。结果:各干预组血清T-AOC、SOD、GSH、GSH-PX、CAT及胰岛素水平均显著高于糖尿病安静组(p<0.05),MDA含量及血糖浓度显著低于糖尿病安静组(p<0.05),其中补充葛根素+运动组较补充葛根素组和运动组也有显著性差异(p<0.05)。结果表明:运动和补充葛根素均可提高糖尿病大鼠血清抗氧化酶活性,降低脂质过氧化程度,改善胰岛素和血糖水平,而以运动结合补充葛根素效果更加显著。

Objective： To investigate the effect of exercise and puererin on antioxidant capacities of diabetic rats serum. Methods： Adult male streptozotocin-diabetic rats were used as research object. For exercise, puererin supplement and exercise combined with puererin supplement, the changes in T-AOC, CAT, GSH-PX, CAT activity, GSH, MDA contents, blood glucose and insulin were measured. Results： The levels of T-AOC, CAT, GSH-PX, CAT activity and insulin of treated diabetic groups are significantly higher （p〈0.05）, while MDA contents and blood glucose concentration are very lower （p〈0.01） than untreated diabetic group. Similarly, the significant difference also exists between exercise combined with puererin supplement group and exercise group or puererin supplement group （p〈0.05）. Conclusion： Exercise and puererin can enhance serum antioxidant capacities of diabetic rats, reduce lipid peroxidative damage and improve level of blood glucose and insulin. Exercise combined with puererin supplement shows the best effect among all experimental groups. The combination of exercise with puerarin supplement would perform a satisfactory healing for diabetes.