奇可力多糖治疗脂肪肝作用的研究

Study on Therapeutic Effect of Chicory Polysaccharides on Fatty Liver Function of Rat

目的:观察奇可力多糖对脂肪肝大鼠的治疗效果,探讨其药效学机制。方法:采用高脂饮食和白酒灌胃,经8w建立大鼠脂肪肝模型,用奇可力多糖治疗4w,并与东宝肝泰进行对比,观测,血清总胆固醇(TC)、甘油三脂(TG);血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、谷氨酰转肽酶(GGT);肝脂—TG、TC;肝微粒体后上清心肌黄酶(DTD)、超氧化物歧化酶(SOD)、脂质过氧化产物丙二醛(MDA)。结论:奇可力多糖治疗脂肪肝的效应及药效学机制为:调整脂质代谢,降低血清甘油三脂和胆固醇;减轻肝细胞脂肪变性;促进肝细胞功能恢复,有效治疗脂肪性肝炎;抗脂质过氧化,提高抗氧化酶活性、降低脂质过氧化产物含量。

Objective： To observe the therapeutic effect of chicory polysaccharides （CPS） on fatty-liver and investigate its pharmacodynamics. Methods： High fatty diet and white wine perfusate were used to establish the fatty liver model of rat for 8 weeks.Compared with Dongbao Gantai as the control medicine, fatty liver rats were treated by CPS for 4 weeks and contents of TC and TG, activities of ALT, AST, ALP and GGT, contents of Liver-TG and TC, and activities of DTD, SOD and MDA were determined.Conclusion： It was found that the pharmacodynamics and therapeutic function of CPS to fatty liver are： adjusting lipometabolism, reducing TG and TC; decreasing fatty degeneration of liver cell; promoting convalescence of hepatocellular function; and anti-lipid peroxidation increasing the activity of peroxidase and decreasing the content of lipid peroxidation products.