山稔子黄酮类提取物抗自由基作用及体内抗氧化功能的研究

Anti-radical Action and Antioxidant Function in vivo of Flavonoids Extracts from Fructus rhodomyrti

本实验研究山稔子黄酮类提取物的抗自由基作用及体内抗氧化功能。通过测定小鼠血清SOD、GSH-Px活性和MDA含量的变化,研究山稔子黄酮类提取物的体内抗氧化功能;并通过测定山稔子黄酮类提取物清除羟自由基率和抑制超氧自由基率的实验,证明山稔子黄酮类提取物的体外抗自由基作用。结果表明,山稔子黄酮类提取物可显著增强小鼠血清SOD、GSH-Px活性,降低MDA含量,并可有效地清除羟自由基和超氧自由基。说明山稔子黄酮类提取物具有明显的抗自由基作用及体内抗氧化功能。

In this study, by determining changes of activties of SOD and GSH-Px and content of MDA in mice serum, antioxidant function in vivo of flavonoids extracts ofFructus rhodomyrti to mice was investigated, and by determining hydroxyl radical scavenging capacity and inhibition rate to superoxide anion radical of the flavonoids extracts, its anti-radical action in vitro was also investigated. Results showed that the flavonoids extracts ofFructus rhodomyrti have improving effects on activities of SOD and GSH-Px in mice serum and reducing effect on MDA content in mice serum, and they can scavenge hydroxyl radical and superoxide anion radical effectively. The anti-radical action and antioxidant function of flavonoids extracts ofFructus rhodomyrti are validated.