2006年某市269例药品不良反应报告与分析

Analysis and Reports of 269 Cases of ADR in a City in 2006

目的:了解各医院及药品生产、经营企业的药品不良反应(ADR)监测情况,探讨发生ADR的相关因素。方法:采用横断面流行病学方描述法,分别对269例ADR患者的性别、年龄、单位分布、住院与门诊、药物种类、给药途径及临床表现进行统计分析。结果:269例ADR中,男女比为1.24:1,男性多于女性;20～29岁发生ADR (25.65%)多于其他年龄段;医院上报ADR 265例(98.52%);住院者207例(76.95%);静脉给药者241例,占总例数的87.01%;抗微生物药139例(44.27%);中药制剂83例(26.43%);ADR的临床表现,以全身反应为多(44.98%);皮肤及附件损害次之(36.80%)。结论:应加强ADR监测报告,促进临床安全、合理用药。

Objective： To find the situation of ADR from hospitals and drug manufacturing enterprises and study some related factors of ADRs. Method： 269 ADR cases were analyzed with the epiolermiological method in terms of the inpatient, age, sex, route administration, drug category and clinical manifestation, etc. Result： In 269 ADR cases, males were more than females, and the 20 -29 year-old group was more than the other age groups in the ADR occurrence. 265 cases （98.52%） were reported from the hospital, 207 of them （76.95%） from inpatients, 241 cases （87.01%） were involved in intravenous administration, 139 cases （44.27%）, related to antibiotics, and 83 cases（26.43% ）, related to traditional Chi- nese medicine injection. The clinical body symptomatic reaction accounted for 44.98%, and the skin lesion and their accessories, 36.80%. Conclusion： ADR monitoring should be strengthened to promote the rational drug use in the clinic.