3种方案预防抗肿瘤药物所致肝损害的最小成本分析

Three Therapeutic Schemes in the Prevention of Antitumor Drug-induced Hepatic Lesion:Cost-minimization Analyses

目的:评价3种方案预防抗肿瘤药物所致肝损害的经济效果。方法:将148例肿瘤患者随机分为A、B、C组,在化疗的同时,分别给予凯西莱、复方甘草酸苷、还原型谷胱甘肽预防化疗药物所致肝损害,观察各组疗效,并进行最小成本分析。结果:A、B、C组成本分别为1544.00、1588.00、1240.00元,总有效率分别为84.62%、86.67%、83.33%(P>0.05)。结论:C组方案较佳。

OBJECTIVE： To evaluate the economic effects of 3 therapeutic schemes in the prevention of antitumor drug- induced hepatic lesion. METHODS： A total of 148 tumor patients were randomly assigned to receive Tiopronin plus chemotherapy （Group A）, compound glycyrrhizin plus chemotherapy （Group B） or reduced glutathione plus chemotherapy （Group C） to prevent chemical drug - induced hepatic lesion. The curative effects were monitored and the cost - minimization analysis was conducted. RESULTS： The costs in Group A, B, and C were 1 544.00, 1 588.00 and 1 240.00 Yuan, respectively, and the total effective rates in the three groups were 84.62%, 86.67% and 83.33% resoectivelv （P 〉 0.05） . CONCLUSION： Group C is the preferable one among the three groups.