538例腹部手术围术期抗菌药物应用分析

An Analysis of Perioperative Application of Antibiotics in Patients Undergoing Abdominal Surgery

目的:评价我院腹部手术围术期抗菌药物应用情况。方法:对我院2006年1～10月538例腹部手术患者围术期抗菌药物的应用情况进行统计、分析。结果:99.4%的患者应用了抗菌药物,共7大类近40个品种,甲硝唑的应用率最高(占48.6%),其次是替硝唑(占16.9%)、头孢匹胺(占15.8%)、加替沙星(占12.3%)、头孢哌酮/舒巴坦(占10.4%)。最常见联用形式为头孢菌素类/青霉素类/喹诺酮类+硝基咪唑类,占83.6%。结论:我院腹部手术围术期抗菌药物应用在品种选择及治疗性用药上基本合理,但仍存在预防用药时间选择不合理、联用药物较多、配伍不合理等问题,应引起重视。

OBJECTIVE： To investigate the perioperative application of antibiotics in patients undergoing abdominal surgery in our hospital. METHODS： The perioperative application of antibiotics in 538 patients undergoing abdominal surgery from Jan. to Oct. in 2006 in our hospital was analyzed statistically. RESULTS： 99.4% of the cases had been treated with antibiotics, which totaled 7 categories （nearly 40 kinds）, with Metronidazole showing the highest proportion （48.6%）, followed in descending order by Tinidazole （ 16.9% ）, Cefpiramide （15.8%）, Gatifloxacin （ 12.3 % ）, and Cefoperazone / Sulbactam （10.4%）. The combination of cephalosporins / Penicillin or Quinolone with Nitroimidazole accounted for 83.6% among all the drugs used in combination. CONCLUSION： The application of antibiotics for abdominal surgery in our hospital is reasonable on the whole, while great importance should be attached to the following problems such as irrational medication time in preventive medication, high proportion of drugs used in combination, incompatibility and so on.