Th2细胞因子与支气管哮喘发病机制的研究进展

Progress of Th2 cytokines and bronchial asthma pathogenesis

支气管哮喘（简称哮喘）是由多种细胞和细胞因子参与的肺部慢性炎症性疾病。发病机制尚未完全清楚，目前认为Th1／Th2反应失衡导致Th2细胞过度激活是其重要的免疫学机制之一，Th2细胞产生的多效性细胞因子白介素4（IL-4）、IL-5和IL-13在此过程中发挥巨大作用，与哮喘发病密切相关。

Bronchial asthma（asthma） is a chronic inflammatory disease oI the lung,winch is invoived with various cells and cytokines. The pathogenesis of asthma is not well-known yet. Now it is recognized that the imbalance of Th1/Th2 response leading to excessive activation of the Th2 cells is one of the important mechanisms of immunology. The polyphenic cytokines produced by Th2 cells,such as IL-4,IL-5 and IL-13, have been certified to play a significant role in this process and are related with asthma pathogenesis.