肝细胞癌癌组织中uPA及其受体的表达及意义

Expression and clinical significance of uPA,uPAR in hepatocellular carcinoma

目的探讨肝细胞癌(HCC)的发生机制。方法通过组织芯片及免疫组化法测定HCC癌组织中uPA及其受体(uPAR)的表达,并与肝硬化及正常肝组织比较。结果uPA在HCC、肝硬化、正常肝组织中的阳性表达率分别为74.0%、46.7%、20%,两两比较,P均<0.05;随HCC分期进展及肿瘤直径增大,uPA表达阳性率逐渐升高。uPAR在HCC、肝硬化、正常肝组织中的阳性表达率分别为70.0%、63.3%、15.0%,与正常肝组织比较,P均<0.05;uPAR阳性表达率随HCC分期进展表达逐渐上升,与肿瘤直径无密切关系。相关分析示,uPA和uPAR具有明显相关性。结论HCC发生和发展是多因素共同作用的结果,其机制可能为uPA及uPAR高表达。

Objective To investigate the mechanism of HCC progression. Methods The expression of uPA and uPAR in hepatoma were tested by using the S-P immunohistochemistry and tissue array. Results The positive rate of uPA expression in HCC, liver cirrhosis and the normal controls were 74%, 46.7%, 20% ,the positive rate in HCC was higher than that in liver cirrhosis and the normal controls（ P 〈 0.05 ）. The positive rate of uPAR expression in HCC, liver cirrho- sis and the normal controls were 70.0% ,63.3% ,15.0% ,the positive rate in HCC was higher than that in the normal controls （P 〈 0.05）. The positive rate of uPA and uPAR increased with the infiltration of HCC. Conclusion The overexpression of uPA and uPAR may play an important role in the development of HCC.