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丹参注射液对妊娠高血压综合征患者血浆TNF-α和TXA_2/PGI_2平衡的调节作用 被引量：4

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摘要 目的观察丹参注射液治疗前后妊娠高血压综合征(PIH)患者血清TNF-α变化和血浆血栓素A2(TXA2)/前列环素(PGI2)平衡变化情况,探讨其治疗PIH的作用机制。方法选择40例轻中度PIH患者,予以丹参注射液8mL静滴10d(丹参治疗组),同时另取正常妊娠40例做对照。ELISA双抗体夹心法检测丹参治疗组治疗前后TNF-α的含量变化,放射免疫法测定治疗前后血浆中TXA2、PGI2其稳定代谢产物TXB2和6-keto-PGF1α的浓度作为判断TXA2和PGI2含量的指标;同时测定正常妊娠对照组的TNF-α、TXB2和6-keto-PGF1α的含量作为比较。结果与正常妊娠对照组相比较,治疗前丹参治疗组患者血清TNF-α含量升高(P<0.05);血浆TXA2含量升高(P<0.05),而血浆PGI2含量降低(P<0.05),TXA2/PGI2比值升高。经过丹参注射液治疗10d后,与治疗前相比较,血清TNF-α含量有所下降(P<0.05);血浆TXA2含量有所下降(P<0.05),血浆PGI2含量有所上升(P<0.05),TXA2/PGI2比值下降。结论PIH病程中存在TNF-α水平升高和TXA2/PGI2比值升高。丹参治疗PIH的作用机制可能是通过降低患者血清TNF-α含量,使血管内皮通透性恢复;同时纠正血管活性物质分泌失衡,使血浆TXA2含量下降,血浆PGI2含量上升,TXA2/PGI2比值失衡恢复,最终使妊娠高血压综合征病程得以逆转。
作者 李智慧 杨美霞 白玉晶
机构地区 浙江省杭州市江干区彭埠镇社区卫生服务中心妇产科 浙江省杭州市笕桥医院妇产科
出处 《海峡药学》 2008年第9期96-98,共3页 Strait Pharmaceutical Journal
关键词 妊娠高血压综合征 丹参 TNF-α TXA2 PG12
分类号 R969.4 [医药卫生—药理学]
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海峡药学
2008年 第9期

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