中医药对恶性胶质瘤患者生活质量和生存期的影响

Effect of Traditional Chinese Medicine on Quality of Life and Survival Period in Patients with Maligant Glioma

目的:探讨中药治疗能否延长恶性胶质瘤患者生存期和提高患者生活质量,阐明中药治疗恶性胶质瘤的临床疗效。方法:中医药组21例,采用中医药治疗,口服,21天为1个周期;中医药加化疗组22例,采用联合化疗方案配合中医药治疗,21天为1周期,两组均治疗4个周期。结果:中医药加化疗组中位生存期20个月,中医药组中位生存期18个月;中医药加化疗组1、2、3年生存率分别为81.82%、77.78%、57.14%,中医药组1、2、3年生存率分别为90.48%、78.95%、60.00%,两组差异无统计学意义(P>0.05);中医症状积分、生活质量及KPS评分中医药加化疗组治疗前分别为(16.11±2.91)、(54.06±4.93)、(64.44±3.18);治疗后分别为(19.38±4.78)、(50.17±7.26)、(60.19±7.90),治疗前后生活质量及KPS评分比较差异有统计学意义(P<0.05);中医药组治疗前分别为(15.95±2.87)、(54.06±3.98)、(64.71±6.23),治疗后分别为(10.35±5.38)、(59.65±4.03)、(69.51±3.28),治疗前后比较差异均有统计学意义(P<0.05),但趋势是向好的方向;不良反应发生率中医药组明显低于中医药加化疗组(P<0.05)。结论:中医药组治疗能提高患者生活质量,延长患者生存期,不良反应小。

Objective： To investigate the effect of traditional Chinese medicine （TCM） on quality of life （QOF） and survival period in patients with maligant glioma,and thus exploring its clinical efficcaey. Methods：TCM therapy appliead in the 21 patients assigned in the TCM group （ Group Ⅰ ） included intrarenous injection of cinobufotalin, or orally taking of anti - cance Chinese herbs. The same TCM was also applied in the 22 of the combined treatment group（ Group Ⅱ ） ,but in combined use of chemotherapeutic protocol, twenty - one days was taken as one cycle and the patients received 4 cycles of treatment. Results ： The median survival perioed in group II was 18 months,while it was 20 months in group I ;the 1 - ,2 - ,3 -year survival rates in group Ⅱ were 81.82% ,77.78% ,57.14% ,and those in the group I survival were 90.48% ,78.95% and 60.00% ,respeetively with insignificant difference between the two group（ P 〉 0.05 ）. The scores of TCM symotom, QOF and KPS in the group 11 （16.11 ± 2.91 ）, （54.06 ±4.93） and （64.44 ± 3.18） before treatment, and （ 19.38 ± 4.78）, （50.17 ± 7.26） and （ 60. 19 ± 7.90） after treatment, respectirely, showing a statistically significant worsening tendency in the latter two . While the three scores in the group I were （15.95±2.87） ,（54.06±3.98） and （64.71±6.23） before treatment,and （10.35±5.38） ,（59.65 ±4.03） and （69. 51 ± 3.28） after treatment, respectively, showing significant improvement （ P 〈 0.05 ）. And the adverse reaction occurrence was significantly less in group I than that in group Ⅱ. Conclusion：Chinese medicine treatment can improve the QOF and prolong the survival period of patients with maligant glioma few side effects.