益肾通络方对C-BSA肾病综合征大鼠模型的整体治疗作用

Pharmacodynamic Study of Yishen Tongluo in Rats with Nephrotic Syndrome by C-BSA

目的:观察益肾通络方对阳离子牛血清白蛋白(C-BSA)大鼠模型的整体治疗作用。方法:采用C-BSA复制肾病综合征大鼠模型,随机分为3组,即模型组,肾炎四味片组,益肾通络方组,每组各10只,并以10只同批正常大鼠为正常组。分别测定大鼠24h尿蛋白,血清白蛋白,血肌酐,血尿素氮;观察大鼠肾组织病理形态,测定面积比。结果:益肾通络方组24h尿蛋白含量、血清肌酐、血尿素氮下降(P<0.01);血清白蛋白提高(P<0.01);肾脏病理损害均有不同程度减轻,面积比减少(P<0.01);其作用优于模型组和肾炎四味片组(P<0.05,P<0.01)。结论:益肾通络方对肾病综合征大鼠有良好的治疗作用,能改善相关蛋白,改善肾功能,减轻肾脏病理损害。

Objective： To study the holistic effect of Yishen Tongluo on treating rats with nephrofic syndrome （NS）. Methods ：50 rat models made by cationic bovine serum album/n（ C - BSA） were devided into five groups at random,including the pathological pattern group, the control group （Shenyan Siwei Pian, SYSW） and Yishen Tongluo （YSTL） group. Each experimental group consisted of 10 rats and the normal group contained 10 normal rats in the same batch. All rots were examined 24 hours later for urine protein quantity （24huPro） ,albumin（Alb） ,serum creatinine（Scr） and blood urea nitrogen（BUN）. Their pathological forms were also observed and positive area ratio examined. Results： In YSTL goup, the 24huPro, Scr and BUN decreased （ P 〈 0. 01 ）, while Alb increased（P 〈0. 01 ）. Also,in YSTL group,the pathological damage, positive area ratio decreased in kidney（ P 〈0. 01 ）. It was much better than either the pathological pattern group or SYSW one respectively（P 〈 0. 05,P 〈 0. 01 ）. Conclusion：YSTL had obvious effects on rats with NS. It could improve the relative proteins and the functions of kidney, and reduce the pathological damages.