痫样放电与血清神经元特异性烯醇酶变化的关系研究

The relationship between status epilepticus and the changes of neuron-specific enolase

目的探讨血清神经元特异性烯醇酶(NSE)在癫痫控制中的诊断价值。方法采用酶联免疫分析法检测癫痫病人有痫样放电者外周血NSE的浓度。结果常规脑电图出现痫样放电波及24h脑电监测每屏都存在痫样放电波者(频发组)血清NSE浓度为(14.15±0.64)μg/L,与对照组(7.98±0.48)μg/L比较差异有高度显著性(P<0.01);与常规脑电图未能发现痫样放电波及24h脑电监测痫样放电波发生次数<10次者(非频发组)的(11.02±4.12)μg/L比较差异也有高度显著性(P<0.01)。结论痫样放电引起血清NSE升高,对脑细胞存在损伤,血清NSE检测对药物控制癫痫的评价有重要价值,动态检测可帮助判断预后。

Objective To investigate the values of serum neuron- specific enolase （NSE） in predicting the prognosis of epileptic seizures control. Methods An enzyme- linked immunosorbent assay was used to detect the peripheral blood NSE concentration in patients with epileptic seizures. Results In patients with EEG waves after seizure and with waves in each screen during 24h - EEG monitoring （the frequent seizure group）, the serum NSE level was （ 14.15± 0.64）μg/L and was significantly higher than that in the control group （7.98 ± 0.48）μg/L, （ P 〈 0.01）. In patients without EEG waves after seizure and the epileptic attack occurred less than 10 times during Z4h - EEG monitoring （ non-frequent seizure group）, the NSE level was （11.02 ＋ 4.12）/,g/L and was also significantly higher than the frequent seizure group （ P 〈0.01）. Conclusion Epileptic seizures can increase the serum NSE, and may injure the brain cells. Serum NSE determination is of great value in evaluating the efficacy of the drug - control for epilepsy and predicting the prognosis.