亚低温联合高压氧治疗脑出血术后临床效果观察

Mild hyperthermia in combination with hyperbaric oxygenation in treatment of post cerebral hemorrhage surgery

目的探讨亚低温联合高压氧(HBO)治疗脑出血术后的临床效果。方法选择66例脑出血术后患者随机分为亚低温联合HBO治疗组和对照组各33例;对照组接受常规综合治疗,治疗组在此基础上行早期亚低温联合HBO治疗。观察两组患者术后1周颅内压(ICP)、入出院时临床格拉斯哥昏迷量表(GCS)评分、动脉血氧分压、血氧饱和度以及治疗后6个月格拉斯哥结局量表(Glasgow Outcome Scale,GOS)评定预后的情况,比较两组临床疗效。结果治疗组患者术后1周ICP显著低于对照组(P<0.01),动脉血氧分压、血氧饱度明显提高(P<0.01),GCS评分和GOS分级明显优于对照组(P均<0.01)。结论脑出血术后患者经亚低温联合HBO治疗能明显提高疗效和改善患者的预后,减少后遗症的发生,提高生活质量。

Objective To evaluate the clinical efficacy of mild hyperthermia in combination with hyperbaric oxygenation in treatment of post cerebral hemorrhage surgery. Methods 66 patlents with post cerebral hemorrhage surgery participated in this study were divided into two groups, the therapeutic group （33 cases ） and the control group （33 cases）. The control group received traditional complex treatment, based in this treatment, the thera- peutic group were also given hyperthermia in combination with hyperbaric oxygenation. The intra- cranial pressure （ICP） at one- week after surgery and clinical Glasgow Coma Scale （CKPS） at admission to hospital and PaO2 and SaO2 and Glasgow Outcome Scale （GOS） were measured 6 months after treatment. Compared the clinical efficacy between the two groups. Results One week after treatment, ICP in the therapeutic group was lower than the control group （ P 〈0.01）, and PaO2 and SaO2 increased significantly （ P 〈0.01）, GCS and GOS scores were superior to the control group （ P 〈 0.01） Conclusion The efficacy of post cerebral hemorrhage surgery can be enhanced via mild hyperthermia in combination with hyperbaric oxygenation and the prognosi can also be improved, and it can decrease incidence of sequel and improve the quality of life.