盐酸丁咯地尔治疗急性脑梗死40例

Effect of Buflomedil Hydrochloride on 40 Cases of Acute Cerebral Infarction

目的观察盐酸丁咯地尔对急性脑梗死的治疗作用。方法对80例急性脑梗死患者随机分为丁咯地尔治疗组和常规治疗组各40例,分别采集患者治疗前和治疗后第1、3、7 d外周血标本,检测TNF-α、IL-1水平,同时对患者治疗前及治疗后第3、7、14 d进行神经功能缺损程度评分。结果丁咯地尔治疗组第1、3、7 d血TNF-α水平较常规治疗组明显降低(P<0.01);治疗组第3、7 d血IL-1水平较常规组有明显下降(P<0.01);治疗组第3、7、14 d神经功能缺损程度评分较常规治疗组有明显改善(P<0.01)。结论盐酸丁咯地尔对急性脑梗死有显著治疗作用。

Objective To investigate the effects of buflomedil hydrochloride on acute cerebral infarction.Methods 80 patients were randomly divided into the buflomedil hydrochloride-treat group（40 patients） and the control group（40 patients）.Blood test was taken before treatment and 1,3,7 days after treatment.Tumor necrosis factor alpha（TNF-α）and Interleukin-1（IL-1） levels were checked in 1,3 and 7 days after treatment.At the same time score of neurological deficits were checked before treatment and 3,7,14 days after treatment.Results The levels of TNF-α in buflomedil hydrochloride treatment group were obviously lower than the control group at the 1s,3rd and 7th day（P〈0.01）;IL-1 level was much lower at 3 and 7 days after treatment in treatment group than the control group（P〈0.01）;There was a significant difference in the score of neurological deficits at the 3rd,7th and 14th day after treatment between the two groups（P〈0.01）.Conclusion buflomedil hydrochloride has significant effect on acute cerebral infarction.