茜草饮片炒炭前后药理作用的比较

Pharmacologic action comparison of india madder root before and after charcoal

目的:探讨茜草、茜草炭饮片抗炎、镇痛、活血化瘀、止血等药理作用的区别。方法:对同一批次茜草药材炮制成的茜草、茜草炭饮片水煎液予不同剂量小鼠灌胃给药,采用小鼠耳廓肿胀法比较二甲苯所致小鼠耳廓肿胀的影响;采用扭体法比较茜草饮片炒炭前后镇痛作用的区别;采用剪尾法、毛细管法比较茜草炒炭前后止血作用的区别;用地塞米松造血瘀模型,比较茜草饮片炒炭前后活血化瘀作用的区别。结果:茜草抗炎、镇痛和活血化瘀作用强于茜草炭;茜草有止血作用,但弱于茜草炭。结论:茜草炮制后,抗炎、镇痛、活血化瘀等药理作用减弱,止血作用增强。

Objective ：To explore the pharmacodynamic differences of india madder root before and after charcoal in antiinflammatory,ease pain, promoting blood circulation for removing blood stasis and hemostasis function. Methods： The india madder root and india madder root charcoal decoction pieces were processed by the same one operation, then the water decoction of them were given to the mouse by intragastric administration in different dosages. The method of auricle tumefaction was adopted to compare the antiinflammatory function, body wrings was adopted to compare the ease pain function, to compare the bemostasis function of india madder root before and after charcoal by snipping off the mouse＇s tail and capillary method. Blood stasis model was made by injecting Dexamethasone Sodium Phosphate, then to compare the promoting blood circulation for removing blood stasis function of india madder root before and after charcoal of india madder root before and after charcoal. Results： India madder root decoction pieces is more effective than india madder root charcoal decoction pieces in antiinflammatory, ease pain, promoting blood circulation for removing blood stasis, but less effective in hemostasis. Conclusion： The function of antiinflammatory ,ease pain, promoting blood circulation for removing blood stasis of india madder root were less effective after charcoal, but the fuction of hemostasis was more effective.