希罗达联合周剂量艾恒治疗晚期消化道肿瘤临床观察

The Clinical Observation of the Combination of Xeloda with Weekly Dose of Oxaliplatin in Treatment of Patients with Advanced Enteron Tumor

目的观察希罗达联合周剂量艾恒治疗晚期消化道肿瘤的疗效和毒副反应。方法希罗达1 250 mg/(m2.d)分2次口服,d1-14,艾恒60 mg/m2静脉滴入d1,8。结果32例中CR 2例,PR 16例。总有效率(CR+PR)为56%,主要毒副反应为恶心、呕吐,感觉性神经毒性,药物热,口腔黏膜炎,腹泻,手足综合征等。结论希罗达联合周剂量艾恒方案对晚期消化道肿瘤有效且安全。

Objective To observe therapeutic effect and toxicity of the combination of xeloda with weekly dose of oxaliplatin in treatment of patients with advanced enteron tumor. Methods Xeloda was given from the first day to the fourteen days, with the dosage of 1 250 mg/（ m^2 · d） , this dosage was taken orally by patients in two proportions in a day. Oxaliplatin was used by dropping in vein on the first, eighth day, with the dosage of 60 mg/m^2. Results The total effective rate was 56% （ CR 2, PR 16）. The main toxicity was nausea, emesis, feeling neurotoxicity, drug fever, mucositis, diarrhea, extremity syndrome. Conclusion The combination of xeloda with weekly dose of oxaliplatin in treatment of patients with advanced enteron tumor was effective and secure.