降钙素原在小儿肺炎诊断中的应用

The clinical application of procalcitonin in diagnosis of pneuminia in children

目的比较分析病毒性肺炎与细菌性肺炎患儿血清降钙素原(PCT)水平,探讨血清降钙素原在细菌性肺炎患儿中的诊断意义,为临床抗生素的使用提供依据。方法42例肺炎患儿,男24例,女18例,平均年龄5.6岁,其中病毒性肺炎25例,细菌性肺炎17例。采用半定量固相免疫测定法测定患儿血清中的PCT。PCT水平分为<0.5ng/mL、≥0.5ng/mL、≥2ng/mL和≥10ng/mL4个等级,进行χ2检验。结果细菌性肺炎组患儿血清PCT水平高于病毒性肺炎组,差异有显著性意义(P<0.01)。结论血清PCT是小儿细菌性肺炎的敏感标志物之一,血清PCT检测有助于小儿肺炎的诊断及鉴别诊断,可作为临床抗生素的使用依据。

Objective To analyze the serum level of procalcitonin （PCT） in children with bacterial or viral pneumonia, explore its diagnostic value in diagnosis of bacterial pneuminia in children, and so as to provide evidence for clinical use of antibiotics. Methods A total of 42 children with pneumonia （mean age was 5.6 yrs, including 24 boys and 18 girls） were divided into viral neumonia group （n= 25） and bacterial neumonia group （n= 17）. Semi-quantitative solid-phase immunoassay was applied to measuring serum procalcitonin. There were four PCT grades： 〈0. 5 ng/mL, ≥0. 5 ng/mL, 2 ng/mL and ≥10 ng/mL. X^2 test was performed. Results The serum level of PCT was more elevated in bacterial neumonia group than that of viral neumonia group, and the difference was statistically significant （P〈0.01）. Conclusion As a sensitive marker of bacterial pneumonia in children, serum procalcitonin contributes to diagnosis and differential diagnosis of pneumonia in children, which may provide basis for clinical use of antibiotics.