摘要
目的研究^153钐-乙二胺四甲撑膦酸(^153Sm-EDTMP)治疗肺癌、乳腺癌及前列腺癌骨转移所致骨痛的疗效。方法静脉注射^153Sm—EDTMP,给药剂量18.5~37.0MBq/kg(0.5~1.0mCi/kg)体重,每隔1~2个月注射1次。结果^153Sm—EDTMP治疗肺癌、乳腺癌及前列腺癌骨转移所致骨痛的总有效率分别为68.5%、89.3%及100%,且乳腺癌和前列腺癌的疗效与肺癌相比有统计学意义(P〈0.05),81.5%患者白细胞或血小板计数一过性减少。结论放射性核素治疗以成骨为主的骨转移灶,止痛效果明显,方法简便,不良反应小。
Objective To observe the effect of ^153Sm-EDTMP for treating bone metastases of lung cancer, breast cancer and prostate cancer . Methods A hundred and sixty-six patients with bone metastases were intravenously given ^153Sm-EDTMP, 18.5 - 37 MBq/kg ( 0.5 - 1.0mCi/kg ) body weight, once a month or every 2 months. Results The effective rate of bonepain palliation of ^153Sm-EDTMP treating bone metastases of lung cancer, breast cancer and prostate cancer were 68.5% , 89.3% and 100% respectively. Furthermore there was significant difference between lung cancer and breast cancer (P〈0.05), 81. 5% of patients suffered from side effect of transient teukopenia or thrombocypenie. Conclusion ^153 Sm-EDTMP shows effective in treating bone metastases of breast cancer and prostate cancer, with easy application, rare side effect.
出处
《中国医药》
2008年第10期615-616,共2页
China Medicine