Ghrelin在生殖系统中的作用

The Role of Ghrelin in Reproduction

Ghrelin是1999年发现的一个含有28个氨基酸残基的多肽，为生长激素促分泌素受体（GHS—R）的内源性配体，具有调节能量平衡等多种生物学功能。近年来许多研究表明Ghrelin对生殖激素、性腺、胎儿的发育、妊娠等均有一定的影响，并且Ghrelin及其受体广泛存在于生殖轴中。笔者就Ghrelin在生殖系统方面的研究做一综述。

Ghrelin, the endogenous ligand of GH secretagogue receptor type , has emerged as a pleiotropic modulator of diverse biological functions, including energy homeostasis and lately reproduction. We reviewed recent reports evaluating the reproductive effects and sites of action of ghrelin,with particular emphasis regarding. It＇s role as a molecule integrating reproductive function.