乳腺相关生理及病理因素对妇女患乳腺癌的影响

Effects of breast-associated physiological and pathological factors on female breast cancer

目的研究乳腺相关生理及病理因素对妇女乳腺癌患病的影响,为乳腺癌的防治提供依据。方法采用病例对照研究方法,问卷调查1997年1月至2007年4月入院并经病理组织学确诊的女性乳腺癌生存病例200例及同时段年龄相近的非乳腺癌人群200例。利用SPSS10.0的logistic回归模型进行数据录入和分析。结果单因素和多因素分析筛选出有意义的生理及病理危险因素为体重指数(BMI)较大、绝经年龄大、乳腺增生、乳腺癌家族史;保护因子为月经持续天数长。结论BMI较大、绝经年龄大、乳腺增生、乳腺癌家族史可增加乳腺癌的患病风险;月经持续天数长可降低乳腺癌的发病风险。

Objective To study the effects of breast-associated physiological and pathological risk factors on female breast cancer in order to provide a basis for prevention and treatment of breast cancer. Methods A case control study was carried out. From January 1997 to April 2007, 200 female patients with breast cancer diagnosed by pathohistological examination and 200 non-breast cancer agematched women were questionnaired. SPSS 10. 0 was used to analyze the data. Results Univariate and multivariate logistic regression showed that greater body mass index （BMI） , late menopause, hyperplasia of mammary glands and family history of breast cancer were positively related to breast cancer; long menstrual period was negatively related to breast cancer. Conclusions Greater BMI, late menopause, hyperplasia of mammary glands and family history of breast cancer are risk factors for breast cancer; long menstrual period is a protective factor.