Osteoglycin高表达降低小鼠肝癌Hca-F细胞淋巴结转移能力
High Expression of Osteoglycin Reduces Lymph Node Metastatic Potential of Mouse Hepatocarcinoma Hca-F Cells
摘要
[目的]研究osteoglycin表达与肿瘤转移的关系。[方法]构建真核表达载体pIRE-Spuro3 osteoglycin(+),将其转染至小鼠肝癌细胞株Hca-F,评价osteoglycin表达对Hca-F细胞转移生物学行为的影响。[结果]转染pIRESpuro3 osteoglycin(+)的Hca-F细胞迁移能力和侵袭能力显著下降;体内试验显示,其外周淋巴结转移率明显降低;然而细胞增殖能力及粘连能力未见明显变化。[结论]高表达osteoglycin降低Hca-F细胞淋巴结转移能力。
出处
《中国肿瘤》
CAS
2008年第10期878-882,共5页
China Cancer
基金
国家自然科学基金(30500586)
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