P16蛋白表达与肺癌的关系

Relationship of Primary Pulmonary Carcinoma with P16 Protein Expression

为探索Ｐ１６蛋白表达与肺癌（ＰＰＣ）的关系，作者应用免疫组织化学技术检测６５例ＰＰＣ组织中Ｐ１６蛋白的表达。结果显示：ＰＰＣ中Ｐ１６蛋白表达的总丢失率为３６．９２％±１８．４５％，其中腺癌（ＡＣ）组为２８．４７％±１６．３３％、鳞状细胞癌（ＳＣＣ）组为３５．９５％±１７．３６％、腺鳞癌（ＡＳＣＣ）组为５７．８８％±１０．１８％。其中６０岁以下组ＳＣＣ与６０岁以上组ＳＣＣ、低分化癌与中分化癌的Ｐ１６蛋白丢失率比较，以及ＡＣ与ＡＳＣＣ，ＳＣＣ与ＡＳＣＣ的Ｐ１６蛋白表达丢失率比较，其差异有显著性（Ｐ＜０．０５）。男性ＰＰＣ与女性ＰＰＣ、左肺ＰＰＣ与右肺ＰＰＣ、以及淋巴结转移性癌与原发性ＰＰＣ的Ｐ１６蛋白表达丢失率比较，其差异无显著性（Ｐ＞０．０５）。本研究结果提示Ｐ１６蛋白可能是ＰＰＣ预后判定的重要指标之一。

This study sought to address the relationship of primary pulmonary carcinoma (PPC) with P16 protein expression. The expression of P16 protein in 65 cases of PPC was examined with immunohistochemical staining. The rate of loss of P16 protein expression in PPC was 36.92%±18.45%. The rate of loss of P16 protein expression in adenocarcinoma (AC) was 28.47±16.33%, that in squamous cell carcinoma (SCC) was 35.95%±17.36%, and that in adenosquamous cell carcinoma (ASCC) 57.88%± 10.18%. There significant differences were in the rate of loss of P16 protein expression between those aged <60 with SCC and those aged >60 with SCC, between low differentiated PPC and intermediate differentiated PPC, between AC and ASCC, and between SCC and ASCC ( P<0.05) . There were no significant differences in the rate of loss of P16 protein between males and females with PCC, between left and right PPC, and between PPC and metastatic pulmonary carcinoma of lymph node ( P>0.05) . These suggest that P16 protein expression may be one of the important standards in estimating the prognosis of patients with PCC.