表皮生长因子受体在人十二指肠溃疡的表达

Expression of Epidermal Growth Factor Receptor in Human Duodenal Ulcer

采用免疫组化法检测了１１１例人十二指肠球部活检标本的表皮生长因子受体（ＥＧＦＲ）表达，结果表明ＥＧＦＲ表达以粘膜上皮细胞膜肠腔面最强，上皮细胞基侧膜和粘膜肌次之，上皮细胞胞浆又次，间质和十二指肠腺也有ＥＧＦＲ表达，淋巴滤泡无ＥＧＦＲ表达。ＥＧＦＲ表达在球部溃疡和溃疡瘢痕有明显增强。ＥＧＦＲ表达强度与粘膜组织炎症程度有关，与性别、年龄无关。本次研究结果提示ＥＧＦＲ与粘膜组织对炎症的适应、溃疡的愈合和组织结构的重建相关。

Expression of epidermal growth factor receptor (EGFR) was studied immunohistochemically in 111 cases of human duodenal bulb biopsy. The results showed that the expression of EGFR was strong on the luminal side of epithelial cell membrane, moderate in the basolateral membrane of epithilial cells and the cells of muscularis mucosae, low in the cytoplasm of the epithelial cells, and lower in the mesenchyma and Brunner′s gland. No expression of EGFR was found in lymphoid aggregates. The expression was evidently stronger in duodenal ulcer and duodenal ulcer scar. EGFR expression was correlated with the severity of inflammation, but was not related to sex and age. In conclusion, the result suggests that EGFR is correlated with mucosal adaptation to inflammation, ulcer healing and tissue reconstruction.