干燥综合征患者泪腺组织的形态及免疫组化研究

Histopathologic and Immunochemical Changes in Sjogren′s Syndrome

为进一步研究干燥综合征的病因、病理机理，对６例该病患者做泪腺组织的光、电镜观察及免疫组化的观察。结果：早期泪腺细胞变性、细胞器改变、其分泌排出功能减低，继而在腺泡、导管间出现淋巴细胞浸润；晚期见大量浸润的淋巴细胞及胶原纤维代替了正常腺体结构。

To research into the causes of sjogren′s syndrome, we investigated the lacrimal gland tissues of 6 cases of sjogren′s syndriome by using electronmicroscopy and immunochemical methods. The results revealed that at the early stage the lacrimal gland cells showed degencration, irregular arrangement and many intracellular vacuoles. At the middle stage, some lymphocytes infliltrated into the gland tissues. And at the advanced stage, lymphocytes and collagenous fibers were there in substitution of gland cells.