摘要
用免疫组化ABC法检测70例消化道肿瘤的P53蛋白表达．结果显示：67例癌组织中P53阳性率为44．5％；P53阳性表达和肿瘤组织学分级、淋巴结转移等有关，并且随PCNA增殖指数分级而明显升高．这表明P53阳性表达可能作为一个重要的预后指标．在癌旁组织及癌前病变中的P53阳性表达提示P53蛋白可能成为消化道肿瘤早期诊断的一个良好指标．
P53 protein expression in 70 tumours of alimentary tract was determined by ABC immunohistochemicaI method. The results showed that P53 positive rate was 44. 5%in 67 carcinomas. P53 positive expression was correlated with histopathologic grade and lymph node metastases, and increased significantly with PCNA proliferative index grade.It is suggested that P53 protein expression may be an important prognostic marker. In premalignant and adjacent dysplasia, P53 positive expression made P53 protein an attractive marker for the early diagnosis of alimentary tract carcinomas.
