灯盏花素和单硝酸异山梨酯治疗顽固性心力衰竭临床观察

目的探讨灯盏花素和单硝酸异山梨酯治疗顽固性心力衰竭（RHF）的临床效果。方法将146例RHF患者随机分成两组，对照组（72例）给予洋地黄、利尿剂、扩血管药、吸氧等常规治疗；治疗组（z4例）在常规治疗的基础上加用灯盏花素20mg、单硝酸异山梨酯1Omg静脉滴注，每日一次，灯盏花素连用14天，单硝酸异山梨酯连用6天后停2天，再连用6天，疗程共14天。治疗前后进行心功能分级评估和超声心脏指数比较。结果治疗组患者心功能和各项心脏指数较对照组改善更为显著（p〈0.01）。结论灯盏花素和单硝酸异山梨酯对顽固性心力衰竭患者疗效显著。

Objective To observe the therapeutic effect on refractory heart failure（RHF） by Breviscapine with isosorbide mononitrate. Methods 146 cases with RHF were randomly divided into two groups.Patients in control group（72 cases）were treated with routine treatment including digitalis, diuretics, vasodilators, oxygen uptake, etc. In addition to the routine treatment,patients in treatment group（74 cases） were treated with 20mg of Breviseapine injection and 10 mg of isosorbide mononitrate injection through intravenous drip once a day for 14 days（Application of isosorbide mononitrate injection was stopped for 2 days in the middle of the course of the treatment）. All the cases were examined by cardiac color ultrasound, heart function evaluation. Results Patients in treatment group had more significant improvements in both heart function and cardiac output than those in control group（P〈0.01）. Conclusion Breviscapine and isosorbide mononitrate are significantly effective to treat refractory heart failure.