人参多糖多相脂质体对免疫功能的影响及抗癌作用

Enhancement of Murine Host Defense Function and Inhibition Effect on Tumor Growth by Polyphase Liposome Encapsulating Ginsen Polysaccharide

以巨噬细胞ＥＡ花环形成率为指标，证明了人参多糖多相脂质体（ＺＭＩ，ＺＭ２）可激活正常或荷瘤小鼠腹腔巨噬细胞ＦＣ受体，将有助于改善机体的免疫功能，增强巨噬细胞对肿瘤的攻击能力．同时还证明，ＺＭ１单用对小鼠Ｓ－１８０肿瘤有轻度抑制作用，作为化疗辅助剂与环磷酰胺、环己基亚硝脲合用有协同作用．与氨甲喋呤合用可明显提高抗癌效果．

Polyphase liposome of Ginseng polysaccharide is a new dosage form of chemotherapeutic adjuvant that can be given p.o..By the observation of the alternation of peritoneal macrophage Fc receptor activity of normal and tumor bearing mice,we demonstrated that ZM1,ZM2 could increase the level of peritoneal macrophage Fc receptors both in their numbers and activities,which may improve host defense function of the mice with or without tumors.We also proved that ZM1 could inhibit S 180 tumor growth slightly.However,ZM1,a chemoutherapeutic adjuvant,when combined with Cyclophosphamide(CY),Lomustin(CCNU) or Methotrexate(MTX) could produce synergetic or reinforcing inhibitory effects on the growth of S 180 tumor.