血管内皮生长因子在胎儿生长受限中的作用

The role of vascular endothelial growth factor in incidence of fetal growth restriction

目的：探讨血管内皮生长因子与胎儿生长受限（FGR）的关系。方法：对2003年1月-2006年4月54例胎儿生长受限孕妇（FGR组）和54例正常孕妇（对照组）分娩后的胎盘及脐带血清进行研究。采用免疫组化检测胎盘组织中VEGF的表达情况；采用ELISA检测脐带血清中的VEGF水平。结果：VEGF在FGR组及对照组胎盘组织滋养细胞及内皮细胞中均有表达，两者表达强度依次为0．08±0．03和0．31±0．04，有极显著性差异（P〈0．01），VEGF在脐带血清中具有相同的变化。结论：VEGF水平减低在FGR中具有重要作用，VEGF可能参与了FGR的发病过程。

Objective： To explore the relationship between the level of vascular endothelial growth factor （VEGF） in pregnant women and incidence of fetal growth restriction （FGR）. Methods： Both placenta and the umbilical cord serum of 54 pregnant women with FGR and 54 normal controls from Jan 2003 to Apr 2006 were analyzed. Immunohistochemistry was used to determine location of and intensity of VEGF staining in placenta of normal pregnancy and pregnant women with FGR; and umbilical cord serum levels of VEGF were analyzed. Results： VEGF were detected in endothelial cells and trophoblastic ceils of placentas in the two groups The expression of VEGF in FGR group （0. 08 ±0. 03） were significantly lower than that in normal controls （0. 31 ±0. 04） （P 〈0. 01） ; and the same changes of VEGF were seen in the umbilical cord serum. Conclusion： The level of VEGF is lower in pregnant women with FGR, which suggest that VEGF may play an important biological role in the pathogenesis of FGR.