女性黄褐斑患者血清性激素水平的检测

Determination of serum sex hormones in female patients with melasma

检测了４８例女性黄褐斑患者和４０例正常对照组的血清性激素水平，发现病例组血清雌二醇、促卵泡素、促黄体素水平显著高于对照组（Ｐ＜０．０１），雄激素水平显著低于对照组（Ｐ＜０．０５），孕激素、泌乳素水平与对照组无显著性差异（Ｐ＞０．０５）；妊娠及口服避孕药对雌二醇的水平有影响（Ｐ＜０．０５）；血清性激素水平在月经是否紊乱的两组患者间无显著性差异（Ｐ＞０．０５）；睡眠、情绪不佳者雄激素水平显著低下（Ｐ＜０．０１）。

Serum levels of sex hormones were determined in 48 female patients with melasma and compared with agematched 40 normal controls. The results showed that the melasma patients presented statistically significant increased levels of estradiol,follicular stimulating hormone, and luteinizing hormone (P<0.01) and decreased level of testosterone (P<0.05), and no differences of serum levels of progestrone and prolactin were found between patients and controls (P>0.05). Pregnancy and oral contraceptives had effect on the level of serum estradiol (P<0.05). The levels of serum sex hormones showed no statistical differences between patients with or without menstrual disorder (P>0.05). The serum level of testosterone in patients with insomnia or in low spirits decreased significantly (P<0.01).