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胰岛素样生长因子结合蛋白-4的生理作用及其作用机理研究

Functions and Its Mechanism of Insulin-like Growth Factor Binding Protein-4
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摘要 IGFBP-4是分子最小的IGFBP,它以糖基化和非糖基化两种形式存在于所有的生物流体中。对IGFBP-4的IGF依赖性和非IGF依赖性作用进行了总结;同时,也对IGFBP-4在繁殖、骨的形成、肾脏疾病和肿瘤形成中的作用进行了探讨。 IGFBP-4 is the smallest of the six high-affinity IGFBPs. It exists in both non-glycosylated and glycosylated forms in all biological fluids. In this review, we summarize the present knowledge of the IGF-dependent and -independent actions of IGFBP4, as well as the biological significance of IGFBP-4.
作者 王桂武 杨福合 孙红梅 刘琳玲
机构地区 中国农业科学院特产研究所
出处 《特产研究》 2008年第3期76-80,共5页 Special Wild Economic Animal and Plant Research
基金 国家科技支撑计划项目(2006BAD6B06)
关键词 胰岛素样生长因子结合蛋白-4 生理作用 作用机理 IGFBP-4 Biological actions Mechanism
分类号 Q78 [生物学—分子生物学]
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参考文献29

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2008年 第3期

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