芪参复康胶囊毒理学研究

Toxicologic Study on Qishen Fukang Capsules

目的:观察动物ig芪参复康胶囊的急性毒性和长期毒性,确定无毒反应的剂量,以评估芪参复康胶囊长期用药的安全性。方法:以最大浓度,最大体积的芪参复康胶囊ig昆明种小鼠,测定最大耐受量;以高、中、低3个剂量对大鼠进行连续灌胃给药26周,于用药13、26周分别各处死1/3动物观察大鼠的生长发育,摄食量,血液细胞学及生化学指标、组织病理学检查,停药观察4周后再处死剩余1/3动物作相应检查。结果:小鼠l天内ig苠参复康胶囊最大耐受量≥39g/kg,各给药组与对照组检查指标,结果统计分析均无明显差异(P>0.05)。结论:ig芪参复康胶囊对小鼠,大鼠均无明显的毒性反应。

Objective： To observe the acute toxicity Qishen Fukang Capsule in mice and its long - period toxicity in rats,so evaluated the safety dosage window in clinical application. Methods： The maximal tolerance dosage was tested by gastric perf usion of single oral dose of Qishen Fukang Capsule. Three groups of rats （ in high, moderate and low dosage of Qishen Fukang Capsule） were administered with repeated gastric perf usion of Qishen Fukang Capsule for 26 weeks. Body weight,hematological and hema to2 biochemical parameters, coefficient and histomorp hological figure oforgans were examined in 13,26 weeks and 4 weeks after t he cessation of Qishen Fukang Capsule. Results： The oral maximal tolerance dose of Qishenfukang Capsule in mice was more than 39g/kg. There was no significant difference between the testgroups and the control in all tested parameters. Conclusion： The Qishen Fukang Capsule have no obviously toxicity,so suggest that Qishenfukang Capsule is safe for clinical application.